The actor was found dead after an apparent drowning in a hot tub on Saturday, according to the Los Angeles Times, citing law enforcement sources.
The American-Canadian actor is best known for playing fan-favourite Chandler Bing for 10 seasons of the sitcom Friends.
From Canada to Hollywood: Matthew Perry's life in pictures
Los Angeles Fire Department spokesman Brian Humphrey told CNN a 911 call came in at 4.07pm (10.07am on Sunday AEDT) for a water rescue emergency.
Humphrey said it was unclear what body of water it was.
LAPD officer Drake Madison would not name the victim, but confirmed that officers responded to a home matching Perry's address at 4.10pm for a death investigation involving a man in his 50s.
US media outlets are reporting Perry had played a two-hour game of pickleball before his death and had sent his assistant out on an errand.
Perry's family have arrived at his home in Bluesail Drive in Pacific Palisades near Malibu on the edge of Los Angeles, the LA Times reports.
His mother Suzanne and her husband, broadcaster Keith Morrison, joined the journalists and LAPD officers on the scene.
Morrison declined to comment, the newspaper said.
Crime scene tape sealed off the home.
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After running the errand for Perry, the assistant reportedly returned to find him unresponsive.
An unnamed representative for Perry confirmed the actor's death to NBC, the network that carried Friends for the entirety of its 10-season run.
Representatives for Perry did not return CNN's request for comment.
There was no sign of foul play, reports say.
A Warner Bros Television Group spokesperson told CNN they were "devastated" by the death.
"Matthew was an incredibly gifted actor and an indelible part of the Warner Bros," it said in a statement.
"The impact of his comedic genius was felt around the world, and his legacy will live on in the hearts of so many. This is a heartbreaking day, and we send our love to his family, his loved ones, and all of his devoted fans."
Early beginnings
Perry was born in Massachusetts on August 19, 1969, and is the son of John Bennett Perry and Suzanne Marie Langford.
His first credited role was a small part in the drama 240-Robert in 1979.
From there other bit parts came his way in shows including Charles in Charge, Silver Spoons and The Tracey Ullman Show.
He was still in high school when he secured his first film role, playing opposite River Phoenix in the 1988 film A Night in the Life of Jimmy Reardon.
He moved to Los Angeles to pursue acting when he was just 15, with his mother, who was once the press secretary of Canadian Prime Minister Piere Trudeau.
Beloved actor Matthew Perry dies at LA home
After graduating, he took his first TV role in the series Second Chance, which was later renamed Boys Will Be Boys.
He also appeared in numerous other TV shows including Growing Pains, Ally McBeal, The West Wing and Scrubs.
After hearing about the early production of Friends he was not initially considered for an audition on the hit show.
Perry would eventually land the iconic role of Chandler Bing, which ran for 234 episodes, alongside Courteney Cox, Jennifer Aniston, David Schwimmer, Matt LeBlanc and Lisa Kudrow.
Off-screen, the actors became as close as their characters on the show, and famously negotiated together to become some of the highest-paid actors on a television series at the time.
A Friends reunion special in 2021 was hosted by James Corden and fed into huge interest in seeing the cast together again, although the HBO Max reunion was the actors discussing the show and not a continuation of their characters' storylines.
Perry received one Emmy nomination for his Friends role and two more for appearances as an associate White House counsel on The West Wing.
Perry's recent memoir
The Emmy-nominated actor published a memoir titled, Friends, Lovers, and the Big Terrible Thing, recounting his life and career on November 22, 2022.
The memoir openly discussed his troubles with drug and alcohol dependence, including his addiction during the filming of Friends.
He also revealed that he nearly died at the age of 49 when his colon burst from opioid overuse.
Doctors gave him only a two per cent chance of survival and he was in a coma for two weeks followed by months more in the hospital.
The actor required 14 surgeries to help repair all of the abdominal damage, and he admitted to having gone to rehab 15 times over the years in hopes of kicking his drug addiction.
Perry was candid in recent years about his struggles with addiction, which he battled even at the height of his career.
"I was taking 55 Vicodin a day, I weighed 128 pounds, I was on Friends getting watched by 30 million people—and that's why I can't watch the show, 'cause I was brutally thin," Perry said in a CBC interview last year.
-Reported with AP, CNN
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2023-10-29 12:07:06Z
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